To better understand the potential non-energy benefits of very high efficiency dedicated outside air systems (also known as very high efficiency DOAS), this literature review summarizes key research, empirical evidence, and studies performed on similar high-performance HVAC approaches that are more prevalent in today’s market, such as conventional DOAS. As very high efficiency DOAS improves upon high-performance HVAC approaches used by conventional DOAS, the non-energy benefits summarized in this report can be assumed to manifest to an equal or greater degree with a very high efficiency DOAS approach.